Wide variation in measured paracetamol concentrations was observed, especially in the oral groups. P values are listed as 1 g IV vs 1 g orally, 1 g IV vs 1.5 g orally and 1 g orally vs 1.5 g orally, respectively. Results are presented as median (range) or p″ (CI). Probability (X < Y) ( p″) with Bonferroni corrected 95% confidence intervals (CIs) were calculated (CIs including 0.5 meet the null hypothesis). 0167 (Bonferroni correction for 3 comparisons for each parameter). The plasma and CSF maximum concentrations ( C max), times to maximum concentrations ( T max), and area under the plasma and CSF concentration-time curves (AUCs) were calculated using noncompartmental techniques. An IV cannula and lumbar intrathecal catheter were used to sample venous blood and CSF, respectively, over 6 hours. Twenty-one adult patients were assigned randomly to 1 g IV, 1 g oral or 1.5 g oral paracetamol. We compared plasma and cerebrospinal fluid (CSF) pharmacokinetics of paracetamol after intravenous (IV) and oral administration to determine dosing regimens that optimize CSF concentrations.
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Langford, BMBS, FRCA, Department of Anaesthesia, Royal Cornwall Hospital, Truro, Cornwall TR1 3LJ, United Kingdom. Reprints will not be available from the authorsĪddress correspondence to Roger A. The authors declare no conflicts of interest. Langford, BMBS, FRCA, is currently affiliated with the Department of Anaesthesia, Royal Cornwall Hospital, Truro, Cornwall, United Kingdom.įunding: This study was funded by the Department of Anaesthesia and Pain Management, Royal Melbourne Hospital. From the *Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia †Anaesthesia, Perioperative and Pain Medicine Unit, ‡Department of Pharmacology and Therapeutics, §Department of Medicine, and ∥Department of Pharmacology, University of Melbourne, Melbourne, Victoria, Australia ♭epartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia and #Faculty of Pharmacy and Pharmaceutical Sciences, Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.